Index Catalog // ScholarsArchive@OSU

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: that dyphyl- line and internal standard separate completely and there is no absorbance from blank

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: of the capsule shell and release of GRF was also studied. Storage for up to 12 months had no effect

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: using a pharmacokinetic model. It was concluded that there was no statistically significant difference

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: the beginning of each treatment. Water was allowed ad lib during this period. No other dietary

The absolute bioavailability of dyphylline tablets in human subjects

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: for subject two. No adverse effects were reported by either subject; blood pressure and pulse rate

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Creator:: Lorskulsint, Duangchit
Abstract:: The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
Resource Type:: Masters Thesis
Full Text:: application of 20% benzocaine -3H in Polyethylene glycol suppository. However, no methemoglobin could be

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Creator:: Chou, Joyce Tian-wei
Resource Type:: Dissertation
Full Text:: 24 hours. A positive correlation was observed between repellency and evaporation of DEET, but no

Prolonged duration of action of dyphylline through prodrugs

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: Dyphylline Esters Using Chloroform-d as the Solvent and TMS as the Internal Standard Reference IV Summary of

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

Creator:: Hsu, Huey-yuh
Abstract:: A high-pressure liquid chromatography method based on reported literature was developed for the quantitative analysis of chlorpheniramine, pseudoephedrine, phenylpropanolamine and acetaminophen in dissolution fluids and urine. The effects of buffer, pH and different concentrations of organic solvent in the mobile phase on chromatographic separation are described in Chapter I. Dissolution...
Resource Type:: Masters Thesis
Full Text:: chromatography. Several mobile phases and internal standards were investigated. The effects of buffer, pH, and

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: acetaminophen concentration versus 128 time curve for subject no.3. Each dose normalized to 325mg dose. A.20

ScholarsArchive@OSU

Assay and pharmacokinetics of dyphylline following oral administration in humans

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

The absolute bioavailability of dyphylline tablets in human subjects

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Prolonged duration of action of dyphylline through prodrugs

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

New product formulation and multiple dose pharmacokinetics of acetaminophen

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