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Filtering by: Creator Lim, Daniel Contributor advisor sim Burrows, Sean M.

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Creator:

Almlie, C. Kyle

Abstract:

Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...

Resource Type:

Dissertation

Full Text:

Mrs. Ball), Randy Miller, Erik Wasinger, Larry and Maureen Kirk, Daniel Edwards, Daniel Clark
Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:

Larkey, Nicholas E.

Abstract:

One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...

Resource Type:

Dissertation
Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

Creator:

Zhang, Lulu

Abstract:

Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...

Resource Type:

Dissertation