Index Catalog // ScholarsArchive@OSU

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Creator:: Alto, Sarah I.
Abstract:: Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Resource Type:: Dissertation

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Creator:: Selman, Wisam H.
Abstract:: Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
Resource Type:: Dissertation

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Creator:: Nagra, Alamjit K.
Abstract:: Immature T cells, known as thymocytes, undergo development through successive stages in the thymus and the periphery to become functional mature T cells. These stages are regulated by sequence specific transcription factors (SSTFs). Two such SSTFs, BCL11B and TCF-1, are both known master regulators of thymopoiesis, which is also known...
Resource Type:: Honors College Thesis

Gene Networks of the Skeletal Muscle Cell

Creator:: Singh, Arun J.
Abstract:: Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
Resource Type:: Dissertation

Regulation by a developmental transcription factor of signaling enzymes related to atrial fibrillation

Creator:: Law, Christina M.
Abstract:: Atrial fibrillation is the most common cardiac arrhythmia, and the mechanisms that lead to this heart defect are not fully understood. Consequently, treatments for this defect do not currently reverse structural or molecular variations that lead to cardiac arrhythmia. Loss of the gene coding for the transcription factor Pitx2 leads...
Resource Type:: Honors College Thesis

Factors that Modify and Control Bcl11b, a Tumor Suppressor Protein

Creator:: Shen, Connie Guo
Abstract:: The experiments explained in this Honors thesis are focused on finding a cellular model for analyzing Bcl11b, a transcription factor dysregulated in 20% of cases of T-cell Acute Lymphoblastic Leukemia (T-ALL). Acute Lymphoblastic Leukemia is the most common childhood cancer. Because T-ALL is a result of incorrect thymocyte development, research...
Resource Type:: Honors College Thesis

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

Creator:: Niibori, Yoshiko
Abstract:: Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result partially...
Resource Type:: Masters Thesis

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Creator:: Parker, Chelsea R.
Abstract:: The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Resource Type:: Honors College Thesis

Regulation of phospholipase C-beta isozymes by calmodulin

Creator:: McCullar, Jennifer Star
Abstract:: Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well characterized, but little is known about other protein interactions that may also regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library with...
Resource Type:: Dissertation

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

Creator:: Salehi, Satin
Abstract:: Herbs have been used for many centuries in diverse civilizations for the treatment of heart disease. Only a few natural supplements claim to have direct cardiovascular actions including hawthorn (Crataegus spp.) and berberine derived from the Berberidaceae family. Several different studies indicate important cardiovascular effects of hawthorn and berberine. For...
Resource Type:: Dissertation

ScholarsArchive@OSU

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Gene Networks of the Skeletal Muscle Cell

Regulation by a developmental transcription factor of signaling enzymes related to atrial fibrillation

Factors that Modify and Control Bcl11b, a Tumor Suppressor Protein

Regulation of inositol phospholipid hydrolysis by extended treatment with angiotensin II in human aortic smooth muscle cells

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Regulation of phospholipase C-beta isozymes by calmodulin

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

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