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Purification of 2,5-dihydroxyacetanilide epoxidase and mechanism of hydroquinone epoxidases

Creator:: Kirchmeier, Marc J.
Abstract:: 2,5-dihydroxyacetanilide epoxidase from Streptomyces LL-C10037 (DHAE I) catalyzes the epoxidation of hydroquinone 4, to form epoxyquinone 7. DHAE I has been purified to homogeneity, with an overall purification factor greater than 23,000. N-terminal and internal amino acid sequences have been obtained from the purified enzyme so that the epoxidase gene...
Resource Type:: Dissertation
Full Text:: Acknowledgments To my major advisor Professor Steven J. Gould for his excellent direction, continuous

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Wityak, John
Abstract:: The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
Resource Type:: Dissertation
Full Text:: F. Abstract Approved: Redacted for Privacy DrkSieven J. Gould The loss of all deuterium labels

Syntheses of labeled putative intermediates in acivicin biosynthesis

Creator:: Jiang, Nan
Resource Type:: Masters Thesis
Full Text:: husband Xingjian and my parents Acknowledgments I am truly grateful to Professor Steven J. Gould, my

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Creator:: Shen, Ben
Resource Type:: Dissertation
Full Text:: approved: Ur. Steven J. Gould Antibiotic LL-C10037a, has now been shown to have the epoxysemiquinone

Studies on advanced intermediates in the biosynthesis of streptonigrin

Creator:: Erickson, W. Randal
Abstract:: Early studies on the biosynthesis of the quinoline quinone portion of streptonigrin, 1, had suggested the intermediacy of novel aromatic amino acids. In order to test this hypothesis, a series of compounds was synthesized and tested for potential incorporation. [4-¹⁵N] 4-Aminoanthranilic acid, 4 5 a , [4-² H] 7-aminoquinaldinic acid,...
Resource Type:: Dissertation
Full Text:: Streptonigrin Abstract Approved: Redacted for privacy -Dr. Steven J. Gould Early studies on the biosynthesis

Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: I am forever indebted to Professors Steven J. Gould and T. Mark Zabriskie whose friendships

Secondary metabolism in Streptomyces murayamaensis

Creator:: Melville, Chris R.
Resource Type:: Dissertation
Full Text:: : Professor Stein J. Gould A multidisciplinary approach to unraveling the biosyntheses of secondary

Cloning and characterization of polyketide biosynthetic gene clusters from Streptomyces murayamaensis, Streptomyces rimosus, and Streptomyces WP 4669

Creator:: Hong, Seong-tshool
Resource Type:: Dissertation
Full Text:: Abstract approved: Stev J. Gould The kinamycin antibiotics produced by Streptomyces murayamaensis are

Studies on naphthyridinomycin biosynthesis

Creator:: He, Weixuan
Resource Type:: Dissertation
Full Text:: presented on May 20. 1992 Stud'estn Naphthyridinomycin Biosynthesis . Steven J. Gould in

Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Creator:: Prabhakaran, P. C.
Abstract:: Feeding of [3-¹³C, 2-¹⁵N]arginine, 38a, unequivocally established that the β- arginine moiety of blasticidin S, 1, was formed from α-arginine by an intramolecular migration of the α-amino group to the β- position. Further feedings using chirally deuteriated arginines 38e and 38f revealed that the aminomutase process occurred with inversion of...
Resource Type:: Dissertation
Full Text:: Acknowledgements I would like to express my gratitude to Professor Steven J. Gould, my research director, for his

ScholarsArchive@OSU

Purification of 2,5-dihydroxyacetanilide epoxidase and mechanism of hydroquinone epoxidases

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Syntheses of labeled putative intermediates in acivicin biosynthesis

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Studies on advanced intermediates in the biosynthesis of streptonigrin

Advanced studies of blasticidin S biosynthesis

Secondary metabolism in Streptomyces murayamaensis

Cloning and characterization of polyketide biosynthetic gene clusters from Streptomyces murayamaensis, Streptomyces rimosus, and Streptomyces WP 4669

Studies on naphthyridinomycin biosynthesis

Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

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