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Filtering by: Creator Kleywegt, Gerard J. Remove constraint Creator: Kleywegt, Gerard J. Contributor advisor sim Ho, Pui Shing Remove constraint Contributor advisor sim: Ho, Pui Shing

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  • Sequence dependent conformational variations in DNA holliday junctions

    Creator:
    Hays, Franklin A.
    Abstract:
    Four-stranded DNA junctions (also known as Holliday junctions) are structural intermediates involved in a growing number of biological processes including DNA repair, genetic recombination, and viral integration. Although previous studies have focused on understanding the conformational variability and sequence-dependent formation of Holliday junctions in solution there have been relatively few...
    Resource Type:
    Dissertation
    Full Text:
    role in the subsequent structure solution and refinement. Zebulon J. R. Jones provided some assistance

  • The effect of cytosine methylation on DNA structure

    Creator:
    Vargason, Jeffrey M.
    Abstract:
    DNA methylation is common in prokaryotes and eukaryotes and has been implicated in various biological roles including gene silencing, X-chromosome inactivation, and genomic imprinting. 5-methylcytosine the "fifth base" of the genetic code comprises 1-3% of the human genome and is primarily found on cytosines within the context of the CpG...
    Resource Type:
    Dissertation