Index Catalog // ScholarsArchive@OSU

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

Creator:: Mollusky, Adina J.
Abstract:: This study applied a virtual version of the Morris water maze (vMWM) task to an examination of age-related differences between younger and older participants, and the impact of prior military service in older men on spatial memory and cognitive flexibility. Participants performed the Logical Memory task that included immediate and...
Resource Type:: Honors College Thesis

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Creator:: Reynolds-Lallement, Nadjalisse C.
Abstract:: This study applied a virtual rendition of the Morris water maze, which is commonly used for assessing spatial memory in rodents, to an examination of age-related differences in spatial learning among 42 younger (18-30 years) and older (>60 years) male human participants. Virtual Morris water maze performance was measured by...
Resource Type:: Honors College Thesis

Assessment of Gut Microbiome Role in Diet-Related Changes in Cognition

Creator:: Caballero-Ignacio, Clarisa
Abstract:: Western diets can influence behavior and gut microbiome due to the excessive intake of high fat and sucrose. Altering the microbiome can also influence the brain and behavior. The hypothesis that was tested was that diet-induced changes in the microbiome cause changes in cognitive abilities. A previous study showed learning...
Resource Type:: Undergraduate Thesis and Presentation

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation

A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory

Creator:: Escobedo, Emily R.
Abstract:: Humans and rodents experience declines in reference (long-term) and working (short-term) memory and cognitive flexibility during the aging process. Aging changes in GluN1 and GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor...
Resource Type:: Undergraduate Thesis

Influences of an Anti-inflammatory Drug, Ibuprofen, on Spatial Memory and NMDA Receptor Subunit Expression During Aging

Creator:: Márquez Loza, Alejandra
Abstract:: One of the first cognitive dysfunctions to arise with aging is memory loss, affecting an estimated 85% of elderly in the U.S. over the age of 80 with Age Associated Memory Impairment. A common feature in humans and animals experiencing memory loss with aging is the decline in N-methyl-D-aspartate (NMDA)...
Resource Type:: Honors College Thesis

A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects ofaging on spatial reference memory

Creator:: Escobedo, Emily R. and Magnusson, Kathy R.
Abstract:: A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 Humans and rodents experience declines in reference (long-term), working (short-term) memory, and...
Resource Type:: Poster

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Creator:: Brim, Brenna L.
Abstract:: As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Resource Type:: Dissertation

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

Creator:: Das, Siba Ranjan
Abstract:: As the aging population continues to grow the world over, age related complications become more and more apparent among the elderly population. One such complication is age associated memory impairment, which makes the elderly more dependent on caregivers early on. NMDA receptors in the brain are important for memory formation,...
Resource Type:: Dissertation

ScholarsArchive@OSU

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Assessment of Gut Microbiome Role in Diet-Related Changes in Cognition

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory

Influences of an Anti-inflammatory Drug, Ibuprofen, on Spatial Memory and NMDA Receptor Subunit Expression During Aging

A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects ofaging on spatial reference memory

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

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