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Filtering by: Committee Member Pearson, G. D. Contributor advisor sim Mathews, Christopher K.

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:

Ji, Jiuping

Abstract:

A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...

Resource Type:

Dissertation

Full Text:

committee members for their advice: Drs. G. D. Pearson, J. Hays, T. Lomax and C. J. Bayne. Finally, my
Mutagenic mechanisms associated with DNA cytosine methylation, DNA base sequence context and DNA precursor pool asymmetry

Creator:

Zhang, Xiaolin

Resource Type:

Dissertation

Full Text:

wish to thank my graduate committee members for their advice: Drs. Tony Chen, George D. Pearson, David
Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:

Song, Shiwei

Abstract:

It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...

Resource Type:

Dissertation

Full Text:

research. My sincere appreciation also extends to the members of my committee, Drs. George D. Pearson