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Filtering by: Advisor Hlebichuk, Joseph F. Remove constraint Advisor: Hlebichuk, Joseph F. Contributor advisor sim McGuire, Joseph Remove constraint Contributor advisor sim: McGuire, Joseph

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  • Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

    Creator:
    Ryder, Matthew P.
    Abstract:
    Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: _____________________________________________________________________ Joseph McGuire

  • Molecular origins of peptide entrapment in polyethylene oxide layers

    Creator:
    Wu, Xiangming
    Abstract:
    A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________________________ Joseph McGuire Karl F. Schilke A more quantitative understanding of