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Filtering by: Creator Hu, Chin-Hwa Remove constraint Creator: Hu, Chin-Hwa Contributor advisor sim Pearson, George D. Remove constraint Contributor advisor sim: Pearson, George D.

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  • Structural requirements for adenovirus DNA replication

    Creator:
    Hu, Chin-Hwa
    Abstract:
    The adenovirus replication origins reside in the inverted terminal repetition (ITR) sequences. Replication proceeds unidirectionally by a strand-displacement mechanism from either or both origins to produce duplex daughter DNA plus a displaced parental strand. The displaced strand can be duplicated by two different routes. The cis pathway involves intramolecular hybridization...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE THESIS OF Chin-Hwa Hu, for the degree of Doctor of Philosophy in Biochemistry and

  • Intramolecular and intermolecular strand hybridization during adenovirus DNA replication

    Creator:
    Xu, Fu-yun
    Abstract:
    Adenovirus initiates strand-displacement DNA replication from origins located in identical inverted terminal repetitions (ITRs). Panhandle structures, formed by base-pairing between ITRs on the displaced strands, have been proposed as replication intermediates for complementary strand synthesis. Plasmid molecules containing a single adenovirus terminal sequence and specially arranged inverted repeat sequences were...
    Resource Type:
    Dissertation
    Full Text:
    , and Chin-Hwa Hu for providing some of the materials and for helping with several experiments. TABLE

  • Sequence conversion during adenovirus DNA replication

    Creator:
    Bennett, Kelly L.
    Abstract:
    The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...
    Resource Type:
    Dissertation
    Full Text:
    very special thanks to Dr. Chin-Hwa Hu for his completely altruistic approach in the laboratory. I