Greater degrees of insulin resistance are associated with increased rates of coronary artery disease (CAD) progression. However, the specific behavioral determinants of insulin resistance are not well known in patients with CAD. Although abdominal obesity contributes to insulin resistance, the extent to which abdominal obesity may modify the relationship between...
Abdominal obesity is a part of insulin resistance syndrome that is closely
linked to increased risk of coronary artery disease (CAD). Because fat tissue acts as
an endocrine target and source of hormone production, increased metabolism or
production of chemical messengers in fat tissue may result in metabolic perturbations
that...
Low physical activity levels and high serum C-reactive protein (CRP) levels are risk factors for coronary artery disease (CAD) in both men and women. However, postmenopausal women who take hormone replacement therapy (HRT) may have increased risk of CAD because of HRT-related increases in serum CRP. There are two manuscripts...
The presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studies suggest that regular endurance exercise, that does...
Individuals with Down syndrome (DS) have less atherosclerosis than others with and without mental retardation (MR). Why individuals with DS do not develop atherosclerosis similarly to others is not known. The insulin resistance syndrome (IRS), a common neuroendocrine disorder underlying cardiovascular disease, has not been investigated in adults with DS...