Index Catalog // ScholarsArchive@OSU

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Creator:: Chen, Danny
Abstract:: Estrogen is a sex hormone responsible for the development and regulation of the reproductive system and secondary sex characteristics. They also play a critical role in the development of breast and uterine cancer. The formation of agonistic metabolites of estrogen, especially 16α-hydroxyestrone, have been found to have cancer-inducing effects meanwhile...
Resource Type:: Honors College Thesis
Full Text:: ) Abstract approved: _____________________________________________________ David E. Williams

Determination of flavin-containing monooxygenase mRNA levels in mouse lung and liver

Creator:: Lo, Pachida C.
Abstract:: We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
Resource Type:: Honors College Thesis

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Creator:: Patel, Karan A.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Resource Type:: Honors College Thesis
Full Text:: Microsoft Word - K. Patel_Thesis_Body.docx Sulforaphane

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: ______________________________________________________ David E. Williams

Acute exposure to ethionamide in an Fmo 1/2/4 null murine model

Creator:: Palmer, Amy L.
Abstract:: The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
Resource Type:: Masters Thesis

Utilization of EpiDerm, a Reconstructed Human Skin Model, in a Translational Mouse to Human Study

Creator:: Ridinger, Elyssa
Resource Type:: Presentation

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Creator:: Larkin, Andrew, Siddens, Lisbeth, and Krueger, Sharon
Abstract:: Epidermal RNA samples from FVB/N mice treated with PAH standards and environmental PAH mixtures were harvested and purified using Trizol extraction and RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5), indicating significant RNA degradation and the need to modify handling, collection, and processing of skin...
Resource Type:: Undergraduate Thesis and Presentation

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF David J. Castro for the degree of Doctor of Philosophy in Toxicology presented on February

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: indole-3- carbinol in the rat AN ABSTRACT OF THE THESIS OF David M. Stresser for the degree of Doctor

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

Creator:: Orner, Gayle A.
Resource Type:: Dissertation
Full Text:: Effects in Trout. Abstract approved: David E. Williams Peroxisome proliferators (PPs) are nongenotoxic

ScholarsArchive@OSU

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Determination of flavin-containing monooxygenase mRNA levels in mouse lung and liver

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Acute exposure to ethionamide in an Fmo 1/2/4 null murine model

Utilization of EpiDerm, a Reconstructed Human Skin Model, in a Translational Mouse to Human Study

Method development for extraction and purification of dermal RNA from FVB/Nmice treated with environmental PAH mixtures

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

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