Index Catalog // ScholarsArchive@OSU

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Creator:: DeHart, Jennifer E.
Resource Type:: Masters Thesis

Mechanistic probes and inhibitors of L-pipecolate oxidase

Creator:: Liang, Xi
Resource Type:: Masters Thesis

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Jackson, Michael D.
Resource Type:: Dissertation

Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

Creator:: Petrossian, Gregory
Abstract:: New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
Resource Type:: Research Paper

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Creator:: Heppe, Kenan G.
Abstract:: F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control....
Resource Type:: Honors College Thesis

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Creator:: Blanchard, David, L.
Abstract:: L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Resource Type:: Dissertation

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Creator:: Fei, Xiaobo
Abstract:: Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
Resource Type:: Masters Thesis

Discovery and identification of antibacterial agents for dental use

Creator:: Kirkpatrick, Adam G.
Abstract:: Dental disease is a very prevalent and costly disease in which the symptoms, not the disease, are currently being treated. The disease is caused by pathogenic oral bacteria, many of which are a part of the Mutans Streptococci. The objective of this thesis was to find a natural substance that...
Resource Type:: Honors College Thesis

ScholarsArchive@OSU

Biosynthesis and modification of the antibiotic enduracidin

Partial purification and characterization of L-pipecolic acid dehydrogenase from rabbit kidney cortex

Mechanistic probes and inhibitors of L-pipecolate oxidase

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Discovery and identification of antibacterial agents for dental use

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