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Filtering by: Contributor advisor sim van Holde, Ken

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

Creator:

Georgel, Philippe, 1961-

Abstract:

The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promoter region of the RNA polymerase I of Acanthamoeba castellanii, placed upstream of four repeats...

Resource Type:

Dissertation
New methods for sedimentation and diffusion analysis of macromolecular structure

Creator:

Demeler, Borries

Abstract:

Methods are presented to acquire data from analytical ultracentrifugation experiments by computer using the absorption optical scanning system of the Beckman Model-E ultracentrifuge. A computer program was written which analyzes sedimentation velocity experiments by the van Holde - Weischet method and by the second moment method. The van Holde -...

Resource Type:

Dissertation
Interaction of linker proteins, H1 and HMG1, with nucleosome reconstituted on positioning sequences

Creator:

An, Woojin

Abstract:

The aim of this research was to gain more understanding on how a linker histone (LH), H1⁰, and high mobility group protein, HMG1, interact with nucleosome. To determine the location of linker proteins, three specific positioning sequences were used to reconstitute core nucleosomes and the binding of H1 and HMG1...

Resource Type:

Dissertation