Index Catalog // ScholarsArchive@OSU

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis

Guinea pig model of mild hyperandrogenemia – is it a suitable model for women with polycystic ovary syndrome (PCOS)? A pilot study

Creator:: Barboza Sagrero, Juriana E.
Abstract:: Polycystic Ovary Syndrome (PCOS) is an idiopathic disorder prevalent in ~5-10% of reproductive-aged women. In PCOS women who become pregnant, many experience complications including increased susceptibility of having a miscarriage, high blood pressure, and gestational diabetes, among others. Additionally, exposure to PCOS may have transgenerational impacts: offspring may be at...
Resource Type:: Undergraduate Thesis

Effects of Error-Management Training on Veterinary Student Performance in Technical Skills Training

Creator:: Meritet, Danielle M.
Abstract:: Conventional training methods in most medical fields seek to avoid errors, framing them as negative consequences instead of as learning opportunities. Error-management training (EMT) contrasts with conventional methods by explicitly encouraging trainees to make errors through low-stakes training modules in an effort to alter perspectives on errors, utilizing them as...
Resource Type:: Masters Thesis

Second nature : domestication as experiment and metaphor in 20th century American psychobiology

Creator:: Blanchard, Nicholas
Abstract:: By 1900 domestication was a promising, if somewhat vexed, subject in biology. Volumes had been written about domestication, but little serious scientific inquiry was directed toward the phenomenon. Expertise lay with practical men, primarily breeders and fanciers. The bulk of scientific commentary on domestication came from anthropologists who derived theories...
Resource Type:: Dissertation

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation

The role of the plasminogen activator system in the etiology of ovarian follicular cysts in dairy cattle

Creator:: McNeel, Anthony Kent
Abstract:: Cystic ovarian disease (COD) is an anovulatory condition in cattle that afflicts between 6-18% of all dairy cows in the US. Ovulation is dependent on the plasminogen activator (PA) family of proteases and protease inhibitor for proteolysis, culminating in follicular rupture. Failure of the follicle to ovulate suggests an aberration...
Resource Type:: Dissertation

Activation, modification and suppression of sex pheromone production in garter snakes

Creator:: Parker, M. Rockwell
Abstract:: Vertebrates communicate with one another and coordinate intraspecific reproduction by using a variety of sexually dimorphic signals, such as plumage, ornaments, sounds, and/or scents. These sexual dimorphisms are maintained by physiological factors, typically sex-specific hormones (though see Chapter 3 for an exception). The purpose of the research in this dissertation...
Resource Type:: Dissertation

Effects of conjugated linoleic acids on PGE₂, PGF₂α and progesterone production by bovine luteal cells in vitro

Creator:: May, Katherine C. P.
Abstract:: Feeding conjugated linoleic acids (CLA) improves reproductive performance in dairy cows; however, the molecular mechanisms by which CLA improves reproduction are not well understood. Therefore, we evaluated whether the CLA isomers, trans-10, cis-12 CLA and cis-9, trans-11 CLA altered synthesis of steroidogenic hormones in bovine luteal cells by measuring concentrations...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Guinea pig model of mild hyperandrogenemia – is it a suitable model for women with polycystic ovary syndrome (PCOS)? A pilot study

Effects of Error-Management Training on Veterinary Student Performance in Technical Skills Training

Second nature : domestication as experiment and metaphor in 20th century American psychobiology

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

The role of the plasminogen activator system in the etiology of ovarian follicular cysts in dairy cattle

Activation, modification and suppression of sex pheromone production in garter snakes

Effects of conjugated linoleic acids on PGE₂, PGF₂α and progesterone production by bovine luteal cells in vitro

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