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Filtering by: Creator Mesecar, Roderick S. Remove constraint Creator: Mesecar, Roderick S. Committee Member Dashwood, Roderick Remove constraint Committee Member: Dashwood, Roderick

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  • Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

    Creator:
    Yu, Zhen
    Abstract:
    The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
    Resource Type:
    Masters Thesis
    Full Text:
    Privacy ACKNOWLEDGEMENT S I would like to express my sincerest gratitude to Dr. David E. Williams and

  • Factors contributing to the formation of CC-->TT tandem mutations

    Creator:
    Skinner, Amy M.
    Abstract:
    The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
    Resource Type:
    Dissertation
    Full Text:
    and antioxidants offered by Dr. Roderick Dashwood. I am also thankful for the support and advice

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
    Resource Type:
    Dissertation
    Full Text:
    broccoli sprouts. Glutathione-S-transferase pi-1 polymorphisms did not affect ITC metabolism

  • DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

    Creator:
    Smith-Roe, Stephanie L.
    Abstract:
    The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
    Resource Type:
    Dissertation
    Full Text:
    direction to my research. I also thank my committee members Dr. Roderick Dashwood, Dr. Mitchell Turker, and

  • Cytoskeletal regulation in cell motility and invasion

    Creator:
    Jang, Hyo Sang
    Abstract:
    Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
    Resource Type:
    Dissertation
    Full Text:
    , Elisar Barbar, Jane Ishmael, Barbara Taylor, and Roderick Dashwood for their interest in my project and