Index Catalog // ScholarsArchive@OSU

Superior Anti-tumor Activity Exhibited From a Gemcitabine Prodrug Incorporated into Lecithin-Based Nanoparticles

Creator:: Sandoval, Michael
Abstract:: Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line...
Resource Type:: Poster, Undergraduate Thesis, and Presentation

Integration of embryonic zebrafish and passive sampling device extracts to explore effects of pesticide mixtures

Creator:: Corvi, Margaret
Abstract:: Pesticides are ubiquitous, with more than one billion tons of pesticide products used in the United States annually. These compounds are characterized by their toxic effects to the target organism; however, pesticides are also well known for their deleterious effects to non-target species. Because pesticides have ecological and human health...
Resource Type:: Undergraduate Thesis and Presentation

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Creator:: Lo, Lalee C.
Abstract:: Tumor necrosis factor alpha (TNF α) and interferon gamma (IFN γ) were initially recognized as inflammatory mediators produced by immune cells in response to infectious agents or foreign material. (1,5) However, over the past decade much research in mammalian species has indicated that these proteins also play key roles in...
Resource Type:: Presentation and Undergraduate Thesis

Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro

Creator:: Bathke, Rebecca E.
Abstract:: Perfluorinated chemicals have been widely used in industry for their superior surfactant qualities. Because of their widespread usage and resistance to photolytic and biodegradation mechanisms, as well as their ability to undergo long-range atmospheric transport, these compounds have become ubiquitous in the world-wide water supplies. Of particular interest are perfluorooctanoic...
Resource Type:: Undergraduate Thesis and Presentation

Development of a colorimetric test kit to determine enzymatically produced pyruvic acid in sweet onions

Creator:: Merrill, Dawn C.
Abstract:: Sweet onions are valued for their unique flavor and praised for their health and dietary character. Onion sweetness is perceived as the degree of pungency decreases. Pungency can be quantitatively determined in onions by measuring enzymatically produced pyruvic acid. The onion industry quantifies a sweet onion as one having a...
Resource Type:: Undergraduate Thesis and Presentation

Survey of rhizosphere associated entomopathogenic fungi on small fruits and Christmas trees in the Willamette Valley, OR

Creator:: Fisher, Joanna J.
Abstract:: The entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana are commercially available as microbial control agents for the black vine weevil, Otiorhynchus sulcatus (F.) (Coleoptera: Curculionidae), the key root-feeding insect pest in Pacific Northwest small fruits and ornamentals. Understanding habitat selection is critical to improve the efficacy, persistence and cost of...
Resource Type:: Honors College Thesis

Developing Trap and Kill Technologies to Improve Management of the Western Spotted Cucumber Beetle (Diabrotica undecimpunctata undecimpunctata) and the Western Striped Cucumber Beetle (Acalymma trivittatum)

Creator:: Alderman, Katie
Abstract:: The western spotted cucumber beetle (Diabrotica undecimpunctata undecimpunctata) and the western striped cucumber beetle (Acalymma trivittatum) are pests of many crops, including vegetable, fruit, and nursery crops. Pesticides are commonly used to control this pest. Trap and kill technologies are under development as use in an alternative control for cucumber...
Resource Type:: Undergraduate Thesis and Presentation

Investigation of microbial extracts as a source of neurological agents

Creator:: Malmo, Jay M.
Abstract:: This study tested natural products from cyanobacteria from the Red Sea in Egypt and marine tunicates from the Algoa Bay in South Africa. Products from marine organisms have been used as lead compounds for the synthesis of new drugs because of their biological activity mechanism. Specifically, these products may contain...
Resource Type:: Research Paper

Pheromone mating disruption of filbertworm moth (Cydia latiferreana)in commercial hazelnut orchards

Creator:: Hedstrom, Christopher
Abstract:: BACKGROUND: Oregon produces 99% of the hazelnuts grown in the United States. The key pest threatening commercial hazelnut orchards in Oregon is Cydia latiferreana (Tortricidae), filbertworm moth (FBW). Currently, most growers control FBW with one to two applications of esfenvalerate (Asana XL), a broad spectrum pyrethroid. Pheromone mating disruption is...
Resource Type:: Undergraduate Thesis and Presentation

Response of reef fish assemblages to overgrowth of the hydrocoral Millepora complanata by the crustose alga Ramicrusta sp.

Creator:: Adams, AnnaRose
Abstract:: Natural disturbances and human activities can alter the benthic composition of coral reefs and other marine ecosystems. Reef fishes that associate with particular structures on the sea floor, such as coral heads, may be vulnerable to perturbations of those habitats. The spread of a newly discovered crustose alga (Ramicrusta sp.)...
Resource Type:: Honors College Thesis

Quantification of Cytokine Production Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Determine Potential Role in Suppression of the Immune Response in a Graft versus Host (GvH) Model

Creator:: Magaña, Laura Cristal
Abstract:: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...
Resource Type:: Undergraduate Thesis and Presentation

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Creator:: Bratton, Daniel
Abstract:: The oilseed crop Limnanthes alba (white meadowfoam) is grown in Oregon. Methods were developed for the production of a liquid-based bioherbicide from meadowfoam seed meal (MSM). It was determined that glucosinolate-containing extracts of MSM can be combined with active-enzyme-containing liquid extracts of meadowfoam seed to form a fermented product rich...
Resource Type:: Undergraduate Thesis

Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids

Creator:: Griffith, Anneke M. (Tucker)
Abstract:: Various flavonoid-rich plant extracts have shown efficacy in the treatment of diabetes. Although it is often assumed that dietary flavonoids exert biological antioxidant effects, it is possible that the observed effects work in carbohydrate metabolism. In this study we evaluated the effect of catechins and catechin containing extracts on α-amylase...
Resource Type:: Presentation and Honors College Thesis

Automated annotation of Caenorhabditis mitochondrial genomes and phylogenetic analysis

Creator:: Campbell, Jessica L.
Abstract:: Motivation Relatively little is known about the evolution of mitochondrial genomes between Caenorhabditis species despite decades of research. Both the worldwide search for new nematode species and the effort to increase sequencing speeds require automated tools to quickly characterize and categorize large amounts of data. Results We developed an automated...
Resource Type:: Presentation and Undergraduate Thesis

Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

Creator:: Petrossian, Gregory
Abstract:: New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
Resource Type:: Research Paper

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Presentation and Undergraduate Thesis

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Creator:: Grimwood, Victoria J.
Abstract:: Endogenous circadian clock regulation is essential to normal rhythmicity, particularly the timing of hormone release in the brain. In the context of mammalian reproduction, a surge of a specific hormone, gonadotrophin-releasing hormone (GnRH), initiates a surge of luteinizing hormone (LH) from the pituitary gland, which is required for ovulation in...
Resource Type:: Honors College Thesis

The Release of Nickel from Stainless Steel into Cooked Foods

Creator:: Kamerud, Kristin L.
Abstract:: Toxicological studies show that oral doses of nickel can cause allergic contact dermatitis, and routes of exposure, such as nickel leached from stainless steel cookware are not well characterized. In this study, four variables: grade of stainless steel, cook time, stainless steel seasoning or cooking cycles, and commercial tomato sauces,...
Resource Type:: Undergraduate Thesis and Presentation

Discovery and Characterization of New Cyanobacterial Natural Products from Moorea sp

Creator:: Cowley, Elise Shylo
Abstract:: Natural products (secondary metabolites) are small organic molecules derived from plants, microbes, and marine organisms that have served as a diverse source of useful compounds pharmaceuticals. New biologically active natural products are critical as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce diverse cytotoxic metabolites that represent potential...
Resource Type:: Honors College Thesis

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Creator:: Kashyap, Amita
Abstract:: Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to...
Resource Type:: Honors College Thesis

ScholarsArchive@OSU

Superior Anti-tumor Activity Exhibited From a Gemcitabine Prodrug Incorporated into Lecithin-Based Nanoparticles

Integration of embryonic zebrafish and passive sampling device extracts to explore effects of pesticide mixtures

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro

Development of a colorimetric test kit to determine enzymatically produced pyruvic acid in sweet onions

Survey of rhizosphere associated entomopathogenic fungi on small fruits and Christmas trees in the Willamette Valley, OR

Developing Trap and Kill Technologies to Improve Management of the Western Spotted Cucumber Beetle (Diabrotica undecimpunctata undecimpunctata) and the Western Striped Cucumber Beetle (Acalymma trivittatum)

Investigation of microbial extracts as a source of neurological agents

Pheromone mating disruption of filbertworm moth (Cydia latiferreana)in commercial hazelnut orchards

Response of reef fish assemblages to overgrowth of the hydrocoral Millepora complanata by the crustose alga Ramicrusta sp.

Quantification of Cytokine Production Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Determine Potential Role in Suppression of the Immune Response in a Graft versus Host (GvH) Model

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids

Automated annotation of Caenorhabditis mitochondrial genomes and phylogenetic analysis

Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

The Release of Nickel from Stainless Steel into Cooked Foods

Discovery and Characterization of New Cyanobacterial Natural Products from Moorea sp

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

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