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Filtrado por: Committee Member Field, Katharine G. Degree Name Bachelor of Arts (B.A.)

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:

Kernan, Casey P.

Abstract:

DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...

Resource Type:

Presentation and Undergraduate Thesis
Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

Creator:

Petrossian, Gregory

Abstract:

New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...

Resource Type:

Research Paper