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Filtering by: Alternative title ssim EC 609 Remove constraint Alternative title ssim: EC 609 Committee Member Frei, Balz Remove constraint Committee Member: Frei, Balz

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A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:

Monette, Jeffrey S.

Abstract:

Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...

Resource Type:

Dissertation
A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

Creator:

Kaetzel, Rhonda Sue

Abstract:

Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...

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Dissertation

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on the redox-active protein disulfide isomerase (EC 5.3.4.1), a member of the thioredoxin
Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation
Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:

Smith, Eric Jonathan

Abstract:

Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...

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Dissertation

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Academic Affiliation

Biochemistry and Biophysics2
Environmental and Molecular Toxicology1

Advisor

Hagen, Tory M.3
Reed, Donald J.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2003 to 2014

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Committee Member

Frei, Balz[remove]4
Williams, David3
Hall, Jean2
Baird, William1
Beckman, Joseph1
more Committee Members »

Creator

Kaetzel, Rhonda Sue1
Monette, Jeffrey S.1
Shenvi, Swapna V.1
Smith, Eric Jonathan1

Date

Date range begin – Date range end

Current results range from 2003 to 2014

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Decade

2010-20192
2000-20092

Degree Field

Biochemistry and Biophysics2
Molecular and Cellular Biology1
Toxicology1

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

File Format

application/pdf1

Language

English [eng]4

License

All rights reserved4

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Aging -- Genetic aspects1
Aging -- Molecular aspects1
Aging -- Physiological aspects1
Antioxidants1
Ethylene dichloride1
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