Index Catalog // ScholarsArchive@OSU

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: USEPA, two National Institutes of Health institutes, and the Food and Drug Administration (Collins et

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: - Salguero, Lee, Pineau, & Ward, 1995). AHR-mutant mice also display impaired liver function with

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: areas and hazardous waste sites (Schoeny 1993; Collins et al. 1998). Recently, PAH exposure has been

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Creator:: Poole, Angela Z.
Abstract:: Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
Resource Type:: Dissertation

Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.

Creator:: Almurshidi, Badria H.
Abstract:: Commercial methodologies for producing fungal pigments are of worldwide interest due to the desire to move away from synthetic dyes. Chlorociboria species and Scytalidium species have been reported to produce sufficient yields of pigments for commercial production and have attracted special attention because of their use in spalted wood applications....
Resource Type:: Masters Thesis

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:: Lal, Sangeet Kumar
Abstract:: Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
Resource Type:: Dissertation
Full Text:: EGFR gene have been reported in 36%-60% of tumors (Gladson et al. 2010; Lee et al. 2006). All of

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Creator:: Wilcox, Buck W. L.
Abstract:: Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops for use in breeding and trait development. Errors that occur during DNA replication may cause mutations if they are not corrected...
Resource Type:: Dissertation

Bioactivity Screening and Gene Activation Strategies in Fungi

Creator:: Coddington, Nathan C.
Abstract:: Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
Resource Type:: Honors College Thesis

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Creator:: Creason, Allison L.
Abstract:: Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
Resource Type:: Dissertation

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation

ScholarsArchive@OSU

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.

Calpain 2 proteolysis regulates glioblastoma cell invasion

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Bioactivity Screening and Gene Activation Strategies in Fungi

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

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