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Filtering by: Creator LaDu, Jane Committee Member Freitag, Michael

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:

Lal, Sangeet Kumar

Abstract:

Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...

Resource Type:

Dissertation

Full Text:

with the experiments and taking care of the housekeeping works in the lab. I would like to thank Jane
Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:

Haggard, Derik

Abstract:

There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...

Resource Type:

Dissertation

Full Text:

all of the members of the Tanguay lab that I have worked with: Jane LaDu for training me when I
An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Creator:

Manchanda, Aayushi

Abstract:

Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...

Resource Type:

Dissertation