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Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Creator:

Chavez, Juan D.

Abstract:

Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...

Resource Type:

Dissertation

Full Text:

-dependent acquisition methods combined with different dissociation techniques including CID and ECD, to be
Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:

Beilby, Pamela R.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...

Resource Type:

Dissertation