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Filtering by: Subject Iron -- Absorption and adsorption Remove constraint Subject: Iron -- Absorption and adsorption Committee Member Higgins, Adam Remove constraint Committee Member: Higgins, Adam

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  • Method development for characterizing the hydrophobicity of engineered nanoparticles

    Creator:
    Lee, Fang Yu
    Abstract:
    Characterizing the hydrophobicity of nanoparticles can help us understand their fate and transport in the environment, as well as how nanoparticles may interact with biological systems. However, contact angle and partition coefficient have limitations in measuring the hydrophobicity of nanoparticles, thus promising methods to measuring the hydrophobicity of nanoparticles are...
    Resource Type:
    Masters Thesis
    Full Text:
    needed. Hydrophobic interaction chromatography (HIC) and dye adsorption were used to test the

  • The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

    Creator:
    Alkhatib, Aveen K.
    Abstract:
    The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
    Resource Type:
    Masters Thesis
    Full Text:
    the biopharmaceutical industry to stabilize therapeutic proteins from aggregation and adsorption

  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    and PS 80) will occur with surfactants that stabilize protein mainly by their own adsorption at