Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Alternative title ssim EC 1112 Committee Member Ho, Emily

DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

Creator:

Lytle, Kelli Anne

Abstract:

Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...

Resource Type:

Dissertation
Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:

Nian, Hui

Abstract:

Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...

Resource Type:

Dissertation
From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:

Meeuwsen, Joseph C.

Abstract:

Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...

Resource Type:

Dissertation