Index Catalog // ScholarsArchive@OSU

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation
Full Text:: Outcomes Abstract approved: ______________________________________________________ Molly L

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: capacity. We’ve previously found that administration of dibenzo[a,l]pyrene (15 mg/kg), a potent PAH, late

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Creator:: Conley, Melissa N.
Abstract:: Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
Resource Type:: Dissertation
Full Text:: proximal tibia metaphysis of ovariectomized Sprague Dawley rats as determined by histology

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: -derived, tobacco-specific-carcinogen, 4-(methylnitrosamino)-l-(3-pyridyl)-l- butanone (NNK) [67

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Creator:: Farley, Sherry Mae
Abstract:: The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Resource Type:: Dissertation
Full Text:: Sprague-Dawley rats (Charles River, 250-300g) were housed in plastic cages with hard wood chips, kept on

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Creator:: Armour, Courtney R.
Abstract:: Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
Resource Type:: Dissertation

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Creator:: Hu, Hui
Abstract:: Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
Resource Type:: Masters Thesis
Full Text:: Physiol. 269(6 Pt 2):F846-53 Coolican SA and Hathaway DR (1984). Effect of L-a-phosphatidylinositol on a

Polyunsaturated fatty acid synthesis and type 2 diabetes complications

Creator:: Tripathy, Sasmita
Abstract:: Type 2 diabetes mellitus (T2DM) is a disease of multi-complications affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
Resource Type:: Dissertation
Full Text:: diabetes in male Sprague-Dawley rats have revealed that these rats have a decline in the hepatic nuclear

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

Creator:: Kam, Lynn Cialdella
Abstract:: Menstrual dysfunction (MD), possibly due to lower energy availability (EA), is prevalent in active women and associated with unfavorable heath consequences. PURPOSE: To determine if EA improvements in endurance-trained women, using a daily Carbohydrate-Protein supplement (CHO-PRO), will restore menstrual function and improve musculoskeletal health. METHODS: Athletes with MD (ExMD; n=8;...
Resource Type:: Dissertation
Full Text:: following downhill run (i.e., eccentric exercise) in 10-wk old ovariectomized female Sprague-Dawley rats

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation

ScholarsArchive@OSU

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Polyunsaturated fatty acid synthesis and type 2 diabetes complications

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

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