Index Catalog // ScholarsArchive@OSU

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: E. Shorey for the degree of Doctor of Philosophy in Toxicology presented on May 24, 2012. Title

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Erin Madeen for the degree of Doctor of Philosophy in Toxicology

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF David J. Castro for the degree of Doctor of Philosophy in Toxicology presented on February

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Creator:: Chen, Danny
Abstract:: Estrogen is a sex hormone responsible for the development and regulation of the reproductive system and secondary sex characteristics. They also play a critical role in the development of breast and uterine cancer. The formation of agonistic metabolites of estrogen, especially 16α-hydroxyestrone, have been found to have cancer-inducing effects meanwhile...
Resource Type:: Honors College Thesis
Full Text:: : _____________________________________________________________________ David E. Williams, Mentor, representing Environmental and Molecular Toxicology/Linus Pauling

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Creator:: Jaaf, Shana S.
Abstract:: During the peripartum period (3 weeks before through 3 weeks after calving, a.k.a. “transition”), high producing dairy cows experience, among others, , oxidative stress and immune suppression that compromise performance and increased incidence of diseases.Among trace minerals, supplementation of Selenium (Se) can help to improve the transition by enhancing glutathione...
Resource Type:: Dissertation
Full Text:: (IMI). Letters in the graph denote significant (P<.05) effects of time (T), treatment (Z), and

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented With Walnuts, Raspberries and Other Whole Foods

Creator:: Miranda-Garcia, Omar
Abstract:: Health benefits obtained from consumption of fruits and vegetables have the potential to improve the lifestyle of individuals. The walnut is a polyunsaturated fatty acid (PUFA)-rich whole food that is readily available in the U.S and has been shown to potentially reduce risk of Metabolic Syndrome. Furthermore, consumption of polyphenol...
Resource Type:: Masters Thesis

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Creator:: Farley, Sherry Mae
Abstract:: The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Resource Type:: Dissertation

Metabolic effects of consumption of quercetin, ellagic acid, cherry, and apple phytochemical extracts in high-fat fed mice

Creator:: Smith, Sarah M.
Abstract:: Metabolic improvements and changes in gene expression were measured in mice fed polyphenol-rich extracts derived from apples and sweet cherries, and the common phytochemicals, quercetin and ellagic acid. Polyphenol-rich extracts were produced by solid phase extraction and column chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60%...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented With Walnuts, Raspberries and Other Whole Foods

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Metabolic effects of consumption of quercetin, ellagic acid, cherry, and apple phytochemical extracts in high-fat fed mice

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