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Filtering by: Subject X-rays -- Physiological effect Remove constraint Subject: X-rays -- Physiological effect Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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  • Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

    Creator:
    Coleman, Daniel J.
    Abstract:
    Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
    Resource Type:
    Dissertation
    Full Text:
    Roles for Retinoid-X-Receptors in Solar UV-Induced Melanocyte

  • Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

    Creator:
    Farley, Sherry Mae
    Abstract:
    The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
    Resource Type:
    Dissertation
    Full Text:
    and d4-PK decreased in -T-injected rats demonstrating that vitamin E’s untoward effect on vitamin K

  • Metabolic effects of consumption of quercetin, ellagic acid, cherry, and apple phytochemical extracts in high-fat fed mice

    Creator:
    Smith, Sarah M.
    Abstract:
    Metabolic improvements and changes in gene expression were measured in mice fed polyphenol-rich extracts derived from apples and sweet cherries, and the common phytochemicals, quercetin and ellagic acid. Polyphenol-rich extracts were produced by solid phase extraction and column chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60%...
    Resource Type:
    Masters Thesis
    Full Text:
    rodent diet and fed to C57BL/6J mice along with low-fat (LF, 10% of total kcal) and HF+treatment (HF+X

  • In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

    Creator:
    Cardenas, Andres
    Abstract:
    Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
    Resource Type:
    Dissertation
    Full Text:
    effect of arsenic exposure mediated through DNA methylation in cord-blood. We observed that the inverse

  • The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

    Creator:
    Conley, Melissa N.
    Abstract:
    Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
    Resource Type:
    Dissertation
    Full Text:
    bone turnover……………………………33 2.3.4 Dual-energy X-ray absorptiometry………………………….33 2.3.5

  • Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

    Creator:
    Lee, Sangeun
    Abstract:
    In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
    Resource Type:
    Masters Thesis
    Full Text:
    ................................................................................. 7 γ-Tocopherol’s physiologic effect on human health

  • The role of lutein and zeaxanthin in protecting the retina from light damage

    Creator:
    Derenick, Rhianna A.
    Abstract:
    Purpose: The xanthophyll carotenoids lutein and zeaxanthin are concentrated in the macula lutea of the retina. It is thought that the two plant pigments may play a role in preventing the development of age-related macular degeneration (AMD). Exposure to damaging light plays a role in retinal deterioration and AMD. The...
    Resource Type:
    Masters Thesis
    Full Text:
    can examine biochemical, physiological and dietary mechanisms of carotenoids and light damage at

  • DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

    Creator:
    Lytle, Kelli Anne
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
    Resource Type:
    Dissertation
    Full Text:
    key findings from this paper were that while DHA had little to no effect on circulating endocrine

  • Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

    Creator:
    Hansen, Allysa
    Abstract:
    A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
    Resource Type:
    Masters Thesis
    Full Text:
    positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of

  • Contractile function and calpain activity in mouse skeletal muscle during hypoxia

    Creator:
    Hu, Hui
    Abstract:
    Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
    Resource Type:
    Masters Thesis
    Full Text:
    increase. However, inhibition of calpain activity had no effect on peak power output and isometric force