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  • Structural requirements for adenovirus DNA replication

    Creator:
    Hu, Chin-Hwa
    Abstract:
    The adenovirus replication origins reside in the inverted terminal repetition (ITR) sequences. Replication proceeds unidirectionally by a strand-displacement mechanism from either or both origins to produce duplex daughter DNA plus a displaced parental strand. The displaced strand can be duplicated by two different routes. The cis pathway involves intramolecular hybridization...
    Resource Type:
    Dissertation
    Full Text:
    . Pui Shing Ho, Dr. Dennis Hruby, and Dr. Peter Bottom ley, for their generous help. I also want to

  • Sequence conversion during adenovirus DNA replication

    Creator:
    Bennett, Kelly L.
    Abstract:
    The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...
    Resource Type:
    Dissertation
    Full Text:
    extend my gratitude to my committee members, Dr. Christopher Mathews, Dr. Pui Shing Ho, Dr. Dal lice

  • Effects of nucleosomes on transcription by polymerase I in a reconstituted system

    Creator:
    Georgel, Philippe, 1961-
    Abstract:
    The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promoter region of the RNA polymerase I of Acanthamoeba castellanii, placed upstream of four repeats...
    Resource Type:
    Dissertation
    Full Text:
    his support. All the members of my committee, professor Pui Shing Ho, professor Henry Schaup