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Filtering by: Creator Wickramasekara, S. Committee Member Hsu, Victor L.

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:

Tzeng, Shin-Cheng

Abstract:

Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...

Resource Type:

Dissertation

Full Text:

Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD
Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:

Nirudodhi, Sasidhar N.

Abstract:

Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...

Resource Type:

Dissertation

Full Text:

Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential