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  • Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

    Creator:
    Justen, Savannah F.
    Abstract:
    Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by the tox operon in Burkholderia glumae, in which the encoded protein, ToxD, was previously characterized as essential...
    Resource Type:
    Honors College Thesis
    Full Text:
    Philmus, Mentor, representing the College of Pharmacy Jane Ishmael, Committee Member, representing the

  • Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

    Creator:
    Alto, Sarah I.
    Abstract:
    Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
    Resource Type:
    Dissertation
    Full Text:
    guidance that extend beyond the years spent on this dissertation. To Dr. Jane Ishmael for not only

  • Role of Pitx2 in regulation of cardiac remodelling

    Creator:
    Bhatt, Shachi
    Abstract:
    Background: Heart morphogenesis involves chamber formation followed by septation. Septation is the remodeling of the heart from a single channel peristaltic pump to a two channel pump with one-way valves. Several transcription factors have been implicated in the development of congenital cardiac defects. The paired-like homeodomain transcription factor Pitx2 has...
    Resource Type:
    Masters Thesis
    Full Text:
    committee members, Dr. Jane Ishmael and Dr. Lawrence Curtis. I would like to thank Dr. George Porter Jr

  • Health risk of bathing in Southern California coastal waters

    Creator:
    Brinks, Mitchell V.
    Abstract:
    Bathers exposed to microbiological contamination in coastal waters have an excess risk of gastrointestinal and respiratory illness. The disease burden associated with this risk may be considerable in Southern California, where 50 million annual beach visitors recreate in coastal waters that receive billions of gallons of polluted discharges from nearby...
    Resource Type:
    Masters Thesis

  • Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

    Creator:
    Eida, Auday
    Abstract:
    Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
    Resource Type:
    Dissertation
    Full Text:
    members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

  • Investigation of Procyanidins Used in Botanical Dietary Supplements

    Creator:
    Rue, Emily A.
    Abstract:
    Polyphenolic compounds found in foods such as fruits, vegetables, legumes, nuts and grains, are an integral part of the human diet. Within polyphenols, proanthocyanidins are referred to as condensed tannins and encompass procyanidins, propelargonidins and prodelphinidins. Among these, procyanidins are the largest group. Recent interest in these compounds is related...
    Resource Type:
    Dissertation
    Full Text:
    Drs. Taifo Mahmud, Jane Ishmael, Robert McGorrin, and Jung Kwon for their guidance and intellectual

  • Identification of Cervical Cancer Key Regulators using Network Biology Approach

    Creator:
    Vyshenska, Dariia
    Abstract:
    Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
    Resource Type:
    Dissertation
    Full Text:
    grateful to my committee members, Stephen Ramsey, Jane Ishmael, and Kathy Magnusson for their vital

  • Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

    Creator:
    Kaweesa, Elizabeth Namagoba
    Abstract:
    Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
    Resource Type:
    Masters Thesis
    Full Text:
    Blakemore, Dr. Jane Ishmael, Dr. Kerry McPhail, Dr. Siva Kolluri and Dr. Taifo Mahmud for their insight

  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    Proteau, Dr. Jane Ishmael and Dr. Adrian Gombart for their generous time, support, advice and

  • Weight Stigma and Its Associations with Health Behaviors Among Older Adults

    Creator:
    Phibbs, Sandi Cleveland
    Abstract:
    Having excess weight carries a negative social stigma in the U.S. Previous research has shown that experiencing stigma has negative physical and mental health consequences. Few studies have examined how experiencing weight stigma might act as a barrier to engaging in healthy behaviors among older adults. The purpose of this...
    Resource Type:
    Dissertation
    Full Text:
    , Brian Flay, and Jane Ishmael), thank you for your advice, help, and support! I would like to