Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Johnson, Carrie Committee Member Kioussi, Chrissa

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Creator:

Head, Brian A.

Abstract:

Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...

Resource Type:

Dissertation

Full Text:

wisdom, reagents, or a smile to keep me going. To Carrie Barton, thank you for answering all my text
Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:

Miller, Galen W.

Abstract:

Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...

Resource Type:

Dissertation

Full Text:

Goodale, Joe Fisher, Dr. Kitae Kim, Dr. Siba Das, Dr. Sean Bugel, Eric Johnson, David Mandrell, Chapell
Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:

Axton, Elizabeth R.

Abstract:

Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...

Resource Type:

Dissertation