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Filtering by: Subject Zebra danios as laboratory animals Committee Member Kolluri, Siva

Developing rapid in vivo assays to investigate structure response relationships

Creator:

Truong, Lisa

Abstract:

Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...

Resource Type:

Dissertation

Full Text:

encouraging and providing me lots of opportunities such as going to China, attending numerous conferences
Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:

Haggard, Derik

Abstract:

There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...

Resource Type:

Dissertation

Full Text:

, decreased the expression of many Hox genes as well as enzymes responsible for retinoic acid metabolism