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Filtering by: Creator Groves, Del Roy Remove constraint Creator: Groves, Del Roy Committee Member Leid, Mark Remove constraint Committee Member: Leid, Mark

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  • Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

    Creator:
    Lattier, Vera C.
    Abstract:
    Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
    Resource Type:
    Dissertation

  • Purification and characterization of recombinant calpain-5

    Creator:
    Wang, Mei-Chuan
    Abstract:
    Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
    Resource Type:
    Dissertation
    Full Text:
    residues are similar to other cysteine proteases such as cathepsins B, L, or S (Groves et al., 1998), and

  • Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

    Creator:
    Selman, Wisam H.
    Abstract:
    Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...
    Resource Type:
    Dissertation

  • Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

    Creator:
    Saili, Katerine Schletz
    Abstract:
    Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
    Resource Type:
    Dissertation
    Full Text:
    ), mammary gland proliferation (0.1 mg/kg/day) (Colerangle and Roy 1997), and most recently, abnormal

  • Unraveling tissue regeneration using chemical genetics

    Creator:
    Mathew, Lijoy K.
    Abstract:
    The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
    Resource Type:
    Dissertation