Raspberries are an important commodity worldwide, with the United States (U.S.) leading fourth in global production in 2017. An important factor when shipping propagated Rubus across the globe is the security of clean plant material verified through pathogen detection methods which is vital in preventing disease spread. A raspberry virus...
Bacterial aggregation is a strategy employed by many pathogens to establish infection. Mycobacterium avium subsp. hominissuis (MAH) undergoes a phenotypic change, microaggregation, when exposed to the respiratory epithelium. This aggregation is an important step in the pathogenesis of the infection, laying the foundation for biofilm formation. We therefore compared how...
One assisted reproductive tool used to propagate highly desirable genetics from elite sire and dam matings is embryo transfer. Superovulation is the first part of the overall protocol and it is a required yet costly and biologically stressful procedure in cattle embryo transfer. The process of superovulation results in high...
With continual and worldwide human population growth, our impact on the natural environment expands and intensifies every day. We consume natural resources, burn fossil fuels, and release toxic compounds into the air, water, and earth. We build roads that fragment the landscape, construct new settlements, and develop agricultural lands in...
Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...
The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Emerging infectious diseases are increasing globally and are a threat to human, wildlife, and ecosystem health. The emerging fungal pathogen, Batrachochytrium dendrobatidis (Bd), or amphibian chytrid fungus, is associated with worldwide amphibian population declines and extinctions. Bd has been found on every continent where amphibians exist and has been documented...
Rift Valley fever (RVF) is a mosquito-borne zoonotic viral disease native to the African continent. Outbreaks tend to occur in the wet seasons, and can affect numerous mammalian species including African buffalo. It is debated how the virus survives the inter-epidemic period when it is not detected in mammalian populations,...
Vibrio parahaemolyticus is a Gram-negative, halophilic, human pathogenic bacterium ubiquitous in the marine environment. Like many Vibrio species, V. parahaemolyticus commonly associates with shellfish, particularly oysters. Ingestion of a raw or under cooked oysters contaminated with V. parahaemolyticus can cause gastroenteritis, which is typically self-limiting and rarely causes death. Globally,...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...