Index Catalog // ScholarsArchive@OSU

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences, College of Veterinary

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Biomedical Sciences Jennifer Johns, Committee Member, representing Clinical Pathology Kathy Magnusson

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

Creator:: Koluda, Rony
Abstract:: Radiation exposure to the brain can occur from a variety of events, including space missions, nuclear accidents, and clinical treatments. The effects of high dose radiation are well studied, but those of lower dosage are more elusive. Decline of memory and cognition is observed in patients exposed to low dose...
Resource Type:: Masters Thesis
Full Text:: , and Dr. Kathy Magnusson, for their unwavering support in the completion of my degree despite the

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

Creator:: Singla, Priyanka
Abstract:: Gut-brain communication consists of bidirectional routes between cognitive centers of the brain and peripheral intestines. This bidirectional communication is the result of the interplay between enteroendocrine cells (EECs), enteric nervous system, central nervous system, the vagus nerve, and our microbiota. Multiple studies have associated gut microbial dysbiosis with neurological disorders...
Resource Type:: Masters Thesis
Full Text:: for this project, and Prof. Kathy Magnusson for helping us with the nodose ganglion dissection. Also

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Creator:: Starman, Alia
Abstract:: Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation
Full Text:: , Kathy Magnusson, Barb Taylor, and Tory Hagen, who have provided guidance and encouragement

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: Magnusson, K., analyzed the data. Riordan, R., Dorigatti, A., Galvan, V., and Perez, V.I. wrote the

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Creator:: Poole, Angela Z.
Abstract:: Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
Resource Type:: Dissertation
Full Text:: Magnusson, and Luiz Bermudez for serving on my committee and for all of the feedback and technical support

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: , Dr. Kathy Magnusson, and Dr. David Williams for their guidance and encouragement. I would also

ScholarsArchive@OSU

The Role of Nrf2 in Brain Cellular Senescence

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

The Role of Cellular Senescence in the Development of Alzheimer's Disease

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

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