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Filtering by: Advisor Proteau, Philip J. Remove constraint Advisor: Proteau, Philip J. Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo

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  • Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

    Creator:
    Fernandes, Roberta P. M.
    Abstract:
    In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
    Resource Type:
    Dissertation
    Full Text:
    Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: __________________________________________ Philip J. Proteau The isoprenoid

  • Studies toward the synthesis of coibamide A and analogues

    Creator:
    Li, Dong
    Abstract:
    Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
    Resource Type:
    Dissertation
    Full Text:
    : Philip J. Proteau Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian