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Filtering by: Advisor Siemens, Philip J. Committee Member Mahmud, Taifo

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:

Fernandes, Roberta P. M.

Abstract:

In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...

Resource Type:

Dissertation
Biosynthetic studies of fungal diterpene antibiotics

Creator:

Yao, Qingmei

Abstract:

The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...

Resource Type:

Masters Thesis

Full Text:

Abstract approved: __________________________________________ Philip J. Proteau The isoprenoid