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Filtering by: Creator Blakemore, Paul R. Remove constraint Creator: Blakemore, Paul R. Committee Member Ostroverkhova, Oksana Remove constraint Committee Member: Ostroverkhova, Oksana

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  • Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

    Creator:
    Melbardis, John
    Abstract:
    In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
    Resource Type:
    Masters Thesis
    Full Text:
    Tetraoxobispidine Intermediate Abstract approved: Paul R. Blakemore In previous work (Blakemore et al

  • Analysis of the mechanism of sulfoxide-lithium exchange and the reactive intermediate in stereospecific reagent-controlled homologation (StReCH)

    Creator:
    Hoyt, Amanda
    Abstract:
    The stereospecific reagent-controlled homologation (StReCH) of boronic esters with enantioenriched carbenoid species generated in situ by the addition of organolithium initiators to stereodefined α-chloroalkyl aryl sulfoxides was previously reported. The reaction of an organolithium with an α-chloroalkyl aryl sulfoxide ostensibly generates an α-chloroalkyllithium via sulfoxide-lithium exchange; however, the true nature...
    Resource Type:
    Masters Thesis
    Full Text:
    : Paul R. Blakemore The stereospecific reagent-controlled homologation (StReCH) of boronic esters

  • Synthesis and catalytic applications of derivatives of 7,7'-dihydroxy-8,8'-biquinolyl (azaBINOL)

    Creator:
    Wang, Chao
    Abstract:
    The synthesis of axially chiral polyfunctional derivatives of 8,8'-biquinolyl was explored and the catalytic action of appropriate derivative types investigated in three separate processes: (1) the silylcyanation of carbonyl groups and imines, (2) alkylation of a glycine Schiff-base via phase transfer-catalysis, and (3) direct amide bond formation from simple amines...
    Resource Type:
    Dissertation
    Full Text:
    : Paul R. Blakemore The synthesis of axially chiral polyfunctional derivatives of 8,8´-biquinolyl

  • Total Synthesis of Isotopologues of Xanthohumol and its Congeners for Biological Studies

    Creator:
    Plagmann, Layhna S.
    Abstract:
    Xanthohumol [XN, (E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated chalcone from hops, and its 2,3-dihydro- (DXN) and O6-desmethyl-2,3-dihydro- (DDXN) congeners, are of potential utility for the amelioration of metabolic syndrome; however, their complex bioactivity profiles cannot be properly studied and understood without access to appropriately produced synthetic materials. In the first part of...
    Resource Type:
    Masters Thesis
    Full Text:
    expresses sincere appreciation to the following people: Prof. Paul R. Blakemore, for his outstanding

  • Scanning photocurrent microscopy study of photovoltaic and thermoelectric effects in individual single-walled carbon nanotubes

    Creator:
    DeBorde, Tristan
    Abstract:
    Carbon Nanotubes are a unique family of nanostructures that have shown remarkable promise for mechanical, electrical, and optical applications. Fundamentally similar to the earlier discovered Buckminsterfullerene (C₆₀), carbon nanotubes are hollow cylinders formed from a single sheet of carbon atoms. The research presented in this dissertation investigates several carbon nanotube...
    Resource Type:
    Dissertation
    Full Text:
    . 12 1.5 References 1 Wilder, J. W. G., Venema, L. C., Rinzler, A. G., Smalley, R. E. & Dekker

  • Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

    Creator:
    Maizy, Louis
    Abstract:
    In this thesis, I present studies in the field of terahertz [THz] spectroscopy. It covers both the generation and detection of ultra-fast broadband THz pulses, as well as the transmission properties of vertically grown multi-walled carbon nanotube forests [MWCNTs]. We have found that these vertically grown MWCNTs respond strongly to...
    Resource Type:
    Masters Thesis
    Full Text:
    . Finally, to my prede- cessors Andy Jameson, Joe Tomaino, and Michael Paul, for sharing their knowledge

  • Generating and using terahertz radiation to explore carrier dynamics of semiconductor and metal nanostructures

    Creator:
    Jameson, Andrew D.
    Abstract:
    In this thesis, I present studies in the field of terahertz (THz) spectroscopy. These studies are divided into three areas: Development of a narrowband THz source, the study of carrier transport in metal thin films, and the exploration of coherent dynamics of quasi-particles in semiconductor nanostructures with both broadband and...
    Resource Type:
    Dissertation

  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
    Full Text:
    obliged to Professor Rich G. Carter, Paul R. Blakemore and Kevin P Gable from the Department of Chemistry

  • Expediting the Generation and Analysis of Amorphous Oxide Computational Models: Modeling Complex Systems Swiftly

    Creator:
    Buchanan, Jacob C.
    Abstract:
    In this dissertation, the process of computational modeling of amorphous oxide materials is studied. Amorphous oxides have random atomic arrangements with no long-range structural order which makes it difficult to study structure-property relationships. Despite the difficulties, amorphous oxides have great uses as semiconductors and dielectrics in thin-film transistors. The ability...
    Resource Type:
    Dissertation
    Full Text:
    : ___________________________________________________ Paul Ha-Yeon Cheong In this dissertation, the process of computational modeling of

  • Label free biosensing with carbon nanotube transistors

    Creator:
    Leyden, Matthew R.
    Abstract:
    As electronics reach nanometer size scales, new avenues of integrating biology and electronics become available. For example, nanoscale field-effect transistors have been integrated with single neurons to detect neural activity. Researchers have also used nanoscale materials to build electronic ears and noses. Another exciting development is the use of nanoscale...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE THESIS OF Matthew R