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Filtering by: Creator Hedge, Z. N. Remove constraint Creator: Hedge, Z. N. Committee Member Ostroverkhova, Oksana Remove constraint Committee Member: Ostroverkhova, Oksana

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  • Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

    Creator:
    Nirudodhi, Sasidhar N.
    Abstract:
    Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
    Resource Type:
    Dissertation
    Full Text:
    Sasidhar N. Nirudodhi for the degree of Doctor of Philosophy in Chemistry presented on November 13, 2013

  • Synthesis and Analysis of Heterostructural Semiconductor Alloy Sn1-xCaxCh (Ch=S, Se) and Nitrides Zn1-xWxN and Zn1-x(W1-yMoy)xN

    Creator:
    Matthews, Bethany E.
    Abstract:
    This work explores the synthesis and characterization of the metastable alloys Sn1-xCaxCh (Ch= S, Se) and nitride compounds Zn-W-Mo-N, which have recently been predicted by theorists. Single phase thin films of Sn1-xCaxS are prepared by pulsed laser deposition and radio-frequency magnetron sputtering and of Sn1-xCaxSe are prepared by pulsed laser...
    Resource Type:
    Dissertation
    Full Text:
    alloys Sn1-xCaxCh (Ch= S, Se) and nitride compounds Zn-W-Mo-N, which have recently been predicted by

  • Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

    Creator:
    Melbardis, John
    Abstract:
    In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
    Resource Type:
    Masters Thesis
    Full Text:
    -propanetetracarboxamide (107), followed by N,N´-diallylation of the resulting 2,4,6,8-tetraoxo-3,7- diazabicyclo[3.3.1

  • Analysis of the mechanism of sulfoxide-lithium exchange and the reactive intermediate in stereospecific reagent-controlled homologation (StReCH)

    Creator:
    Hoyt, Amanda
    Abstract:
    The stereospecific reagent-controlled homologation (StReCH) of boronic esters with enantioenriched carbenoid species generated in situ by the addition of organolithium initiators to stereodefined α-chloroalkyl aryl sulfoxides was previously reported. The reaction of an organolithium with an α-chloroalkyl aryl sulfoxide ostensibly generates an α-chloroalkyllithium via sulfoxide-lithium exchange; however, the true nature...
    Resource Type:
    Masters Thesis
    Full Text:
    different organolithium initiators (n-BuLi, t-BuLi, and PhLi). Observation of kinetic resolution in such

  • Synthesis and catalytic applications of derivatives of 7,7'-dihydroxy-8,8'-biquinolyl (azaBINOL)

    Creator:
    Wang, Chao
    Abstract:
    The synthesis of axially chiral polyfunctional derivatives of 8,8'-biquinolyl was explored and the catalytic action of appropriate derivative types investigated in three separate processes: (1) the silylcyanation of carbonyl groups and imines, (2) alkylation of a glycine Schiff-base via phase transfer-catalysis, and (3) direct amide bond formation from simple amines...
    Resource Type:
    Dissertation
    Full Text:
    generally achieved in good to high yield (to aldehydes: 42-92% yield; to ketones: 22-82% yield; to N

  • BaCuChF (Ch = S, Se, Te) p-type transparent conductors

    Creator:
    Zakutayev, Andriy
    Abstract:
    BaCuChF (Ch = S, Se, Te) materials are chalcogen-based transparent conductors with wide optical band gaps (2.9 – 3.5 eV) and a high concentration of free holes (10¹⁸ – 10²⁰ cm⁻³) caused by the presence of copper vacancies. Chalcogen vacancies compensate copper vacancies in these materials, setting the Fermi level...
    Resource Type:
    Dissertation
    Full Text:
    , BaCuSeF is suitable for applications as a p-layer in organic light-emitting diodes, p-i-n double

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    dysferlin and PI(4,5)P2 accumulate at these lesions. Out of dysferlin’s seven C2 domains, only the N

  • Electron-electron interaction driven phenomena in carbon nanotube devices

    Creator:
    Aspitarte, Lee
    Abstract:
    CNTs also offer new opportunities to study new science and develop new technology enabled by their strong electron-electron (e-e) interactions. The lack of dielectric screening inherent in nanoscale structures like CNTs leads to strong e-e interactions, which produce unique physical phenomena. In this thesis, we study the effects of strong...
    Resource Type:
    Dissertation
    Full Text:
    the n-type and p-type Schottky barrier heights. Carbon nanotubes (CNTs) are a promising material

  • Much Ado About Weak Measurement

    Creator:
    Bauml, Benjamin Noë
    Abstract:
    I had to write again. My research lay in science, and it was a science of three parts. The first part made a careful, introductory chapter, begged for by things that were lacking. It summarizes the von Neumann measurement model, derived from the Stern-Gerlach experiment, and it explains how weak...
    Resource Type:
    Capstone Project
    Full Text:
    between the magnets; 2. Bz is the only component of any significance; 3. Bz(z) = B′(z)z within the gap

  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
    Full Text:
    (bottom view)) using B3LYP/6-31G(d) 15 2.2 a) N-N separations in the C2-symmetric diamines DIANANE (26