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Filtering by: Committee Member Zabriskie, Mark T. Remove constraint Committee Member: Zabriskie, Mark T. Committee Member Proteau, Philip Remove constraint Committee Member: Proteau, Philip

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  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    invaluable to me. I am so thankful to my advisory committee members Dr. Mark Zabriskie, Dr. Philip

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    also wish to thank Dr. Mark Zabriskie and Dr. Taifo Mahmud for their advice and support, as well as

  • Structure elucidation and biosynthetic investigations of marine cyanobacterial secondary metabolites

    Creator:
    Nogle, Lisa Marie
    Abstract:
    This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of thirteen new secondary metabolites, the isolation of over fifteen previously reported metabolites and the biosynthetic investigation of two additional cyanobacterial compounds. Two novel lipopeptides were identified from a Lyngbya majuscula and Schizothrix sp. assemblage...
    Resource Type:
    Dissertation
    Full Text:
    the new ct-pyrone malyngamide T. A collection of L. majuscula from Antany Mora, Madagascar, led to