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Characterization of germination of Clostridium perfringens spores from various sources

Creator:: Alnoman, Maryam M.
Abstract:: Clostridium perfringens is a pathogenic anaerobic bacterium able to produce more than 17 toxins, allowing C. perfringins to cause a wide variety of diseases in humans and animals. Beside toxins production, C. perfringens able to form a highly resistance spores can survive in the environments for years. These spores are...
Resource Type:: Masters Thesis

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Creator:: Knight, Eva W.
Abstract:: Myxobacteria represent an interesting class of Gram-negative soil bacteria. These bacteria utilize organic materials from the environment as a food source by the action of their extracellular hydrolytic enzymes. They grow vegetatively in the presence of adequate nutrients. During starvation conditions, however, they aggregate and form multicellular structures called fruiting...
Resource Type:: Masters Thesis

Molecular mechanism of germination of Clostridium perfringens spores

Creator:: Paredes-Sabja, Daniel
Abstract:: Clostridium perfringens is the causative agent of a wide variety of diseases in animals and humans. C. perfringens can produce more than 15 toxins. However, individual strains produce a subset of these toxins. Although a small percentage of C. perfringens isolates (mostly belonging to type A) produce C. perfringens enterotoxin...
Resource Type:: Dissertation

Molecular characterization of an HIV-1 drug target and antiviral compound development

Creator:: Maselko, Maciej
Abstract:: The Human Immunodeficiency Virus -1 (HIV-1) has been the source of substantial human misery since it was first discovered in the early 1980s. Despite remarkable progress that has been made towards understanding HIV- 1, there is no cure, no vaccine and life-prolonging therapies are beyond the reach of millions in...
Resource Type:: Dissertation
Full Text:: commonly occur during intercourse (Shattock & Moore, 2003). Another favorable route is via inflamed or

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Creator:: Arnold, Holly Kristin
Abstract:: The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Resource Type:: Dissertation
Full Text:: questions in light of clinical algorithms, Dr. Dan Rockey who transformed how I think of microbiomes

Natural Products Discovery from Unique Microbial Habitats

Creator:: Gallegos, David A.
Abstract:: Marine natural products possess an abundance of diverse chemical scaffolds with unique biological activities. By targeting unusual or unique microbial environments within varying marine ecologies we can continue to discover novel chemistry with potentially new molecular targets. The research presented here is focused on exploring unusual chemical ecologies and the...
Resource Type:: Dissertation

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:: Smith, Anthony R.
Abstract:: The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...
Resource Type:: Dissertation
Full Text:: graduate committee, Drs. Joe Beckman, Charles Boyer, Balz Frei and Dan Rockey. A special thanks is also

Advances in expression of heterologous protein products by Streptococcus gordonii

Creator:: Warren, Travis Kent
Abstract:: Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
Resource Type:: Dissertation
Full Text:: members, Dr. Kevin Jones, Dr. Nancy Kerkvliet, Dr. Dan Rockey, and Dr. John Dilles who generously gave

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Creator:: Everman, Jamie L.
Abstract:: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
Resource Type:: Dissertation
Full Text:: also like to thank my committee members Dr. Dan Rockey, Dr. Martin Schuster, Dr. Manoj Pastey, Dr

Single-Cell Genomics of Uncultivated Marine Bacteria

Creator:: Landry, Zachary
Abstract:: Historically, the difficulty of obtaining pure cultures of abundant marine microbial plankton has an obstacle to reconstructing the underlying mechanisms of biogeochemistry in the ocean. While a number of dominant marine species from the ocean surface have been cultured, the dominant microbial plankton of the dark ocean proved far more...
Resource Type:: Dissertation

ScholarsArchive@OSU

Characterization of germination of Clostridium perfringens spores from various sources

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Molecular mechanism of germination of Clostridium perfringens spores

Molecular characterization of an HIV-1 drug target and antiviral compound development

Using the Microbial Tree of Life to Describe Mammalian Health and Disease

Natural Products Discovery from Unique Microbial Habitats

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Advances in expression of heterologous protein products by Streptococcus gordonii

Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

Single-Cell Genomics of Uncultivated Marine Bacteria

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