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  • Gene expression in the peripartum canine placenta

    Creator:
    Fellows, Elizabeth Jane
    Abstract:
    This research investigated gene expression in the canine placenta during the peripartum period. Previous studies have recognized molecular changes that occur in the placenta around the time of placental release in other species, but no study has looked at gene expression in the late gestation canine placenta. Of particular significance...
    Resource Type:
    Masters Thesis
    Full Text:
    : Gene Expression in the Peripartum Canine Placenta Abstract Approved: Michelle A

  • Gene Networks of the Skeletal Muscle Cell

    Creator:
    Singh, Arun J.
    Abstract:
    Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
    Resource Type:
    Dissertation
    Full Text:
    such as gene expression correlation or genetic epistasis among the individual trait-associated genes

  • Characterization of the Zea mays ssp. mays TOUSLED-like kinases

    Creator:
    Owusu, Ethel Owusuwaa
    Abstract:
    This dissertation describes the cloning and characterization of the TOUSLEDlike kinases genes of maize (ZmTLKs). The TOUSLED-like kinases (TLKs) are a conserved family of nuclear Ser/Thr kinases in higher eukaryotes. The maize genome has three TOUSLED-like kinase genes (ZmTLK1, ZmTLK2, and ZmTLK3). Based upon sequence similarity, the ZmTLKs are divided...
    Resource Type:
    Dissertation
    Full Text:
    are members of families of closely related genes. Gene families arise through gene duplications and

  • Transcriptomic analysis using high-throughput sequencing and DNA microarrays

    Creator:
    Fox, Samuel E.
    Abstract:
    Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
    Resource Type:
    Dissertation
    Full Text:
    Many genes involved in cell wall biosynthesis exhibit cycling gene expression patterns

  • Orbiting the Genus of False Units: Dynamics of Phage Genomes and Nematode Microbiomes Associated with Pseudomonas spp.

    Creator:
    Ha, Anh D.
    Abstract:
    Pseudomonas is a diverse, ubiquitous, and widely studied genus of bacteria. As Pseudomonas species occupy a wide range of niches in the ecosystem, they have made remarkable biological impacts. Better understanding of Pseudomonas biology, genetic diversity, and functional interactions with other organisms and the environment will provide valuable insights into...
    Resource Type:
    Dissertation
    Full Text:
    , and the evolutionary pressures acting on Pseudomonas phage genes were investigated using whole

  • Evolutionary Genomic Responses to Mitochondrial Dysfunction in Caenorhabditis elegans

    Creator:
    Wernick, Riana I.
    Abstract:
    Understanding the impact of mitochondrial dysfunction on genome evolution has the potential not only to provide new insights on the basic evolutionary processes influencing mitochondrial and nuclear genomes, but may also reveal novel avenues for evolutionary adaptive recovery from harmful mutations. Aberrant mitochondrial activity is fundamental to the pathology of...
    Resource Type:
    Dissertation
    Full Text:
    , these mtDNA mutations were located in genes predicted to physically interact with the gas-1 gene. As

  • Analysis of chlamydial and host proteins associated with infection

    Creator:
    Chu, Hencelyn
    Abstract:
    Chlamydiae are obligate intracellular bacteria that infect a variety of eukaryotic hosts and affect normal host processes. Within host cells, their developmental cycle takes place inside non-acidified vacuoles termed inclusions. An inclusion membrane composed primarily of secreted chlamydial synthesized proteins called Incs encloses the inclusion. At this location, Incs have...
    Resource Type:
    Dissertation
    Full Text:
    species, but the genes flanking this gene are also conserved (123). Bannantine et al also determined

  • Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

    Creator:
    Tivey, Trevor R.
    Abstract:
    Cnidarians and their symbiotic dinoflagellates form a productive mutualism that shapes marine environments. In this symbiosis, dinoflagellate species from the family Symbiodiniacea reside within cnidarian host gastrodermal cells and provide the host with photosynthetically fixed carbon in exchange for host metabolites. This nutritional exchange allows both partners to thrive in...
    Resource Type:
    Dissertation
    Full Text:
    pathways are differentially expressed, including complement pathway genes and thrombospondin-type1 repeat

  • Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

    Creator:
    Beilby, Pamela R.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
    Resource Type:
    Dissertation
    Full Text:
    genetic mutation associated with ALS disease pathogenesis was discovered - the G93A mutation to the gene

  • Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

    Creator:
    Clark, Sarah A.
    Abstract:
    Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
    Resource Type:
    Dissertation
    Full Text:
    paralogs, while all other species only contain the gene for one light chain 3 protein, which