Index Catalog // ScholarsArchive@OSU

Proteins in Motion: Protein Dynamics of Cataracts, and Interactions Between the COVID-19 Virus and its RNA Genome

Creator:: Masson-Forsythe, Heather M.
Abstract:: Just as the structure of a protein determines its function, protein motions and lack-of-structure are also key to regulating protein behavior. The human eye lens is made up of high concentrations of extremely stable crystallin proteins, but even in this context, small motions over time can cause a loss of...
Resource Type:: Dissertation

The Effect of Protein Nitration on Cell Survival Pathways in Schwann Cells

Creator:: Graumann, Oliver W.
Abstract:: Neurofibromatosis type 2 (NF2) is a genetic disorder caused by the inactivation of the merlin tumor suppressor gene. NF2 patients develop bilateral vestibular schwannomas (VS) and other nervous system tumors with no effective drug treatment option. In pathological conditions, including NF2, production of the oxidant peroxynitrite leads to protein tyrosine...
Resource Type:: Honors College Thesis

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation

Alpha-tocopherol is a potential diagnostic indicator of metabolic diseases in early lactation dairy cows, α-tocopherol is a potential diagnostic indicator of metabolic diseases in early lactation dairy cows

Creator:: Qu, Yang
Abstract:: Milk fever (MF), retained placenta (RP), and left displaced abomasum (LDA) are three common and costly metabolic diseases in cows during the first days of lactation. Some studies suggest that circulating concentrations of α-tocopherol (ATOC) are decreased by these three diseases. It is, however, unknown if and how long lower...
Resource Type:: Masters Thesis

Cortisol, abdominal obesity, and reductions in inflammation after cardiac rehabilitation in non-diabetic coronary patients

Creator:: Ogimoto, Kayoko
Abstract:: Abdominal obesity is a part of insulin resistance syndrome that is closely linked to increased risk of coronary artery disease (CAD). Because fat tissue acts as an endocrine target and source of hormone production, increased metabolism or production of chemical messengers in fat tissue may result in metabolic perturbations that...
Resource Type:: Dissertation

Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

Creator:: Crimp, Caitlin A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (B[a]P), are environmental pollutants linked to increased disease susceptibilities. Alpha-Tocopherol (αT) supplementation decreases B[a]P-DNA adducts in smokers, particularly women; but the mechanism is unknown. To test the hypothesis that αT protection from B[a]P exposure is gender-dependent, male and female rats received 7 daily subcutaneous...
Resource Type:: Honors College Thesis

Effect of dietary fatty acids, time of feeding and immune response in poultry

Creator:: Gonzalez, Dulmelis
Abstract:: In the presence of internal or external stressors, the body requires sources of energy that aide cells to combat inflammation. Fatty acids are an important source of energy and are vital components of cell membranes. Dietary fatty acids (n-6 and n-3) are of importance in immune function because they are...
Resource Type:: Masters Thesis

An evaluation into the optimization and application of supercritical fluid extraction and the processing impact on the components in filtrated buttermilk powder

Creator:: Spence, Amy J.
Abstract:: The milk fat globule membrane, a major component in buttermilk, contains many complex lipids known to be involved in a variety of biological processes. Phospholipids, including sphingolipids, exhibit antioxidative, anticarcinogenic, and antiatherogenic properties and have essential roles in numerous cell functions. Filtration coupled with supercritical fluid extraction (SFE) may provide...
Resource Type:: Dissertation

The role of zinc in the molecular and cellular events in the prostate

Creator:: Yan, Michelle
Abstract:: Zinc is an essential mineral that is integral to many proteins and transcription factors that regulate key cellular functions. The normal prostate accumulates high concentrations of zinc; however, malignant tissues have significantly lower zinc levels. This unique relationship between zinc and the prostate has sparked interest in the role of...
Resource Type:: Dissertation

ScholarsArchive@OSU

Proteins in Motion: Protein Dynamics of Cataracts, and Interactions Between the COVID-19 Virus and its RNA Genome

The Effect of Protein Nitration on Cell Survival Pathways in Schwann Cells

Analysis of Cancer Progression by Establishing Quantitative Assessments of Zebrafish Xenografts

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Alpha-tocopherol is a potential diagnostic indicator of metabolic diseases in early lactation dairy cows, α-tocopherol is a potential diagnostic indicator of metabolic diseases in early lactation dairy cows

Cortisol, abdominal obesity, and reductions in inflammation after cardiac rehabilitation in non-diabetic coronary patients

Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

Effect of dietary fatty acids, time of feeding and immune response in poultry

An evaluation into the optimization and application of supercritical fluid extraction and the processing impact on the components in filtrated buttermilk powder

The role of zinc in the molecular and cellular events in the prostate

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