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  • The influence of aryl hydrocarbon receptor activation on T cell fate

    Creator:
    Funatake, Castle J.
    Abstract:
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
    Resource Type:
    Dissertation