Index Catalog // ScholarsArchive@OSU

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Creator:: Quarles, Lucas W.
Abstract:: Contaminants can exist in a wide range of states in aqueous environments, especially in surface waters. They can be freely dissolved or associated with dissolved or particulate organic matter depending on their chemical and physical characteristics. The freely dissolved fraction represents the most bioavailable fraction to an organism. These freely...
Resource Type:: Masters Thesis
Full Text:: W. Quarles for the degree of Master of Science in Toxicology presented on August 5, 2009

A study of antimutagenicity in yogurt

Creator:: Sudarshan, Nadathur R.
Abstract:: The purpose of this study was to identify antimutagens in yogurt active against the experimental colon carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Our initial experiments showed that acetone extracts of yogurt, or milk fermented by various lactic acid bacteria were antimutagenic against MNNG and 3,2'-dimethyl-4-aminobiphenyl (DMAB) in the Ames test (Salmonella typhimurium TA...
Resource Type:: Dissertation
Full Text:: antimutagens in yogurt active against the experimental colon carcinogen, iV-methyl-W-nitro-N-nitrosoguanidine

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: in cardiac mitochondria, young and old F344 rats were pair-fed LA [0.2% (w/w) in the diet] against

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: epithelialgeschwulste. Mitt. Med. Fak. Tokio, 15: 295-344, 1915. 4. Cook, J. W., Hewett, C. L., and Hieger, I. The

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: high performance liquid chromatography (HPLC). All other chemicals were from Sigma (St. Louis, MO

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Creator:: Tsai, Hsi-Wen
Abstract:: Zebrafish (Brachydanio rerio) are small, freshwater teleost fishes in the family Cyprinidae, the true minnows. They are native to the tropical latitudes of India, but have become widespread through their use as aquarium fish and as models for several branches of biological research. Their ease of rearing, short generation time,...
Resource Type:: Dissertation
Full Text:: rerio) AS A MODEL FOR CARCINOGENESIS Chapter 1 INTRODUCTION H-W. Tsai and J. D. Hendricks

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Creator:: De Lorme, Marthah J. M.
Abstract:: 2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
Resource Type:: Dissertation
Full Text:: analytical grade and were purchased from Sigma–Aldrich (St. Louis, MO). An ELGA Ultra PureLab (Cary, NC

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: :51-56. Ryu, B. W., Roy, S., Sparrow, B. R., Selivonchick, D. P. and Schaup, H. W. 1995. Ah receptor

ScholarsArchive@OSU

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

A study of antimutagenicity in yogurt

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search