Index Catalog // ScholarsArchive@OSU

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: carcinogenesis 26 (Lee et al. 1989a, Nunez et al., in press). In the present study, autoradiographs showed

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: . CONTRIBUTION OF AUTHORS Dr. Junga Lee assisted with sample collection and sample preparation for the

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Creator:: Tsai, Hsi-Wen
Abstract:: Zebrafish (Brachydanio rerio) are small, freshwater teleost fishes in the family Cyprinidae, the true minnows. They are native to the tropical latitudes of India, but have become widespread through their use as aquarium fish and as models for several branches of biological research. Their ease of rearing, short generation time,...
Resource Type:: Dissertation
Full Text:: they were fed Oregon Test Diet (OTD) (Lee et al, 1991) twice daily and brine shrimp once daily. This

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Creator:: Li, Shan
Abstract:: Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
Resource Type:: Dissertation
Full Text:: the skin. Ann N Y Acad Sci, 2012. 1257: p. 158-66. 21. Sugawara, T., et al., Tight junction

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: , Roberta Fernandez, David Blanchard, Ann Mintie, and Morgan Parker for their support, friendship

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Creator:: De Lorme, Marthah J. M.
Abstract:: 2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
Resource Type:: Dissertation

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: ., 2004; Lee et al., 2005; Mari-Beffa et al., 1996; Nechiporuk and Keating, 2002; Santamaria et al

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation

ScholarsArchive@OSU

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Role of Transcriptional Factor COUP-TF-interacting Proteins in Skin Permeability Barrier Development, and in Skin Carcinogenesis, and Role of Lipids in Atopic Dermatitis

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

Unraveling tissue regeneration using chemical genetics

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

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