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Microbial Network Recovery by Compositional Graphical Lasso Under Additive Log-Ratio Transformation

Creator:

Tian, Chuan

Abstract:

The interactions between microbial taxa have been under great research interest in the sci- ence community given the microbiome data deluge. Several methods have been proposed to model and estimate the conditional dependency between microbial taxa for their interac- tions, in order to eliminate spurious correlation detections. However, these methods...

Resource Type:

Dissertation

Full Text:

correlation networks for microbiome data, such as SparCC (Friedman and Alm, 2012) , CCLasso (Fang et al
Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:

Song, Zifeng

Abstract:

Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...

Resource Type:

Dissertation
Regularization-Based Data Integration and Its Application to Genome-Wide Association Studies

Creator:

Li, Kai

Abstract:

In genome-wide association studies, it is often challenging to have consistent findings from independent studies. This "lack of reproducibility" issue is partially caused by the relatively small sample size compared to the number of genetic markers in every single study. Therefore, researchers have developed statistical methods to integrate multiple studies...

Resource Type:

Dissertation