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  • Regularization-Based Data Integration and Its Application to Genome-Wide Association Studies

    Creator:
    Li, Kai
    Abstract:
    In genome-wide association studies, it is often challenging to have consistent findings from independent studies. This "lack of reproducibility" issue is partially caused by the relatively small sample size compared to the number of genetic markers in every single study. Therefore, researchers have developed statistical methods to integrate multiple studies...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Kai Li for the degree of

  • Microbial Network Recovery by Compositional Graphical Lasso Under Additive Log-Ratio Transformation

    Creator:
    Tian, Chuan
    Abstract:
    The interactions between microbial taxa have been under great research interest in the sci- ence community given the microbiome data deluge. Several methods have been proposed to model and estimate the conditional dependency between microbial taxa for their interac- tions, in order to eliminate spurious correlation detections. However, these methods...
    Resource Type:
    Dissertation
    Full Text:
    estimators such as those relying on regularization methods (Meinshausen et al., 2006; Yuan and Lin, 2007

  • Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

    Creator:
    Song, Zifeng
    Abstract:
    Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
    Resource Type:
    Dissertation
    Full Text:
    previous and present follow labmates, Dr. Ivegen Motorykin, Dr. Lin Huang, Dr. Armando Alcazar, Dr