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Filtering by: Contributor Wang, Chengshu Creator Spatafora, Joseph W.

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Creator:

Yang, Xiuqing, Feng, Peng, Yin, Ying, Bushley, Kathryn, Spatafora, Joseph W., and Wang, Chengshu

Abstract:

The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades. In this study, the biosynthetic gene cluster is suggested to...

Resource Type:

Article