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From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:

Meeuwsen, Joseph C.

Abstract:

Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...

Resource Type:

Dissertation