The hypothesis of the study was that inhibition of PPAR/ increases glucose uptake and lactose synthesis in bovine mammary epithelial cells by reducing the expression of the glucose transporter mRNA destabiliser calreticulin. Three experiments were conducted to test the hypothesis using immortalised bovine mammary alveolar (MACT) and primary bovine mammary...
Characterization and biological roles of the peroxisome proliferator-activated receptor (PPAR) isotypes are well known in monogastrics, but not in ruminants. However, a wealth of information has accumulated in little more than a decade on ruminant PPARs including isotype tissue distribution, response to synthetic and natural agonists, gene targets, and factors...
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism,
and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment
analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using
Ingenuity Pathway Analysis...
Full Text:
Peripartal Period between Dairy Cows
Overfed or Restricted-Fed Energy Prepartum
Shahzad K, Bionaz M
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism,
and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment
analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using
Ingenuity Pathway Analysis...
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism, and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using Ingenuity Pathway Analysis...